Article

Genetic silencing of AKT induces melanoma cell death

2022-08-15

Abstract excerpt

<h4>ABSTRACT</h4> Aberrant activation of the PI3K-AKT pathway is common in melanoma but efforts to drug this pathway have proven largely ineffective in patients. In this study, we observed that pharmacological inhibition of AKT was ineffective whereas genetic silencing of all three AKT paralogs significantly abrogated melanoma cell growth through effects on mTORC signaling. This phenotype could be rescued by over...

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Literature Corpus work: 0a25b38b-8e30-55c0-a5be-0fa1a95e523f
DOI: 10.1101/2022.08.15.504039

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