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Article

Genetic modifier loci of mouse Mfrp(rd6) identified by quantitative trait locus analysis.

Experimental eye research - 1 Jan 2014

Won Jungyeon, Charette Jeremy R, Philip Vivek M, Stearns Timothy M, Zhang Weidong, Naggert Jürgen K, Krebs Mark P, Nishina Patsy M

Abstract excerpt

The identification of genes that modify pathological ocular phenotypes in mouse models may improve our understanding of disease mechanisms and lead to new treatment strategies. Here, we identify modifier loci affecting photoreceptor cell loss in homozygous Mfrp(rd6) mice, which exhibit a slowly progressive photoreceptor degeneration. A cohort of 63 F2 homozygous Mfrp(rd6) mice from a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24200520
DOI: 10.1016/j.exer.2013.10.020
PMCID: PMC4153418

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