Candidate genetic modifiers of retinitis pigmentosa identified by exploiting natural variation in Drosophila.

Abstract excerpt

Individuals carrying the same pathogenic mutation can present with a broad range of disease outcomes. While some of this variation arises from environmental factors, it is increasingly recognized that the background genetic variation of each individual can have a profound effect on the expressivity of a pathogenic mutation. In order to understand this background effect on disease-causing mutations, studies need...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Drosophila
• Share to Genetic Association Studies