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Article

Stimulation of 5-HT2C receptors improves cognitive deficits induced by human tryptophan hydroxylase 2 loss of function mutation.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Apr 2014

Del'Guidice Thomas, Lemay Francis, Lemasson Morgane, Levasseur-Moreau Jean, Manta Stella, Etievant Adeline, Escoffier Guy, Doré François Y, Roman François S, Beaulieu Jean-Martin

Abstract excerpt

Polymorphisms in the gene encoding the serotonin synthesis enzyme Tph2 have been identified in mental illnesses, including bipolar disorder, major depression, autism, schizophrenia, and ADHD. Deficits in cognitive flexibility and perseverative behaviors are shared common symptoms in these disorders. However, little is known about the impact of Tph2 gene variants on cognition. Mice expressing a human TPH2 variant...

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Identifiers

PMID: 24196946
DOI: 10.1038/npp.2013.313
PMCID: PMC3957106

Genes

TPH2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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