Article
Regulation of the clpP1clpP2 operon by the pleiotropic regulator AdpA in Streptomyces lividans.
Archives of microbiology - 1 Dec 2013
Guyet Aurélie, Gominet Myriam, Benaroudj Nadia, Mazodier Philippe
Abstract excerpt
Insertion of an apramycin resistance cassette in the clpP1clpP2 operon (encoding the ClpP1 and ClpP2 peptidase subunits) affects morphological and physiological differentiation of Streptomyces lividans. Another key factor controlling Streptomyces differentiation is the pleiotropic transcriptional regulator AdpA. We have identified a spontaneous missense mutation (-1 frameshift) in the adpA (bldH) open reading...
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