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Article

Antibody-Dependent Enhancement and the Risk of HIV Infection

1 Nov 2013

Abstract excerpt

Antibody-dependent enhancement (ADE) of infection has been described for a number of viruses including HIV-1. However, the biological role of ADE in HIV disease pathogenesis or in increasing the risk of infection upon exposure is uncertain. In this review, we outline the mechanisms of ADE, as ascertained in vitro. We also discuss several recent human and non-human primate studies that raise concern about ADE...

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PMID: 24191936
DOI: 10.2174/1570162x113116660062

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