Article
BRG1 variant rs1122608 on chromosome 19p13.2 confers protection against stroke and regulates expression of pre-mRNA-splicing factor SFRS3.
Human genetics - 1 May 2014
Xiong Xin, Xu Chengqi, Zhang Yuting, Li Xiuchun, Wang Binbin, Wang Fan, Yang Qin, Wang Dan, Wang Xiaojing, Li Sisi, Chen Shanshan, Zhao Yuanyuan, Yin Dan, Huang Yufeng, Zhu Xuan, Wang Li, Wang Longfei, Chang Le, Xu Chaoping, Li Hui, Ke Tie, Ren Xiang, Wu Yanxia, Zhang Rongfeng, Wu Tangchun, Xia Yunlong, Yang Yanzong, Ma Xu, Tu Xin, Wang Qing K
Abstract excerpt
A single nucleotide polymorphism (SNP) rs1122608 on chromosome 19p13.2 and in the BRG1/SMARCA4 gene was previously associated with coronary artery disease (CAD). CAD and ischemic stroke are both associated with atherosclerosis. Thus, we tested the hypothesis that rs1122608 is associated with ischemic stroke. Further studies were used to identify the most likely mechanism by which rs1122608 regulates...
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