Tuning the range and stability of multiple phenotypic states with coupled positive-negative feedback loops.

Abstract excerpt

Positive feedback loops can produce multistability, resulting in different phenotypic states. However, many transcription networks contain counteracting positive and negative feedbacks. Here we explore the dynamics of an interlinked positive and negative feedback motif based on the galactose-uptake control system of Saccharomyces cerevisiae modified to make the strength of each feedback externally controllable....

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