Article
Impact of HCV genetic differences on pathobiology of disease.
Expert review of anti-infective therapy - 1 Sept 2011
Ripoli Maria, Pazienza Valerio
Abstract excerpt
Multiple HCV genotypes have been isolated worldwide. Genotype seems to be involved in the main pathological aspects of HCV infection. Insulin resistance, steatosis and progression toward cirrhosis, fibrosis and hepatocellular carcinoma establish and develop following genotype-specific mechanisms. Moreover genotype influences pharmacological treatment in term of dose and duration. Pathways involved in cell...
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