Article
Impact of exome sequencing in inflammatory bowel disease.
World journal of gastroenterology - 28 Oct 2013
Cardinale Christopher J, Kelsen Judith R, Baldassano Robert N, Hakonarson Hakon
Abstract excerpt
Approaches to understanding the genetic contribution to inflammatory bowel disease (IBD) have continuously evolved from family- and population-based epidemiology, to linkage analysis, and most recently, to genome-wide association studies (GWAS). The next stage in this evolution seems to be the sequencing of the exome, that is, the regions of the human genome which encode proteins. The GWAS approach has been very...
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