Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Exome localization of complex disease association signals.

BMC genomics - 1 Feb 2011

Lehne Benjamin, Lewis Cathryn M, Schlitt Thomas

Abstract excerpt

BACKGROUND: Genome-wide association studies (GWAS) of common diseases have had a tremendous impact on genetic research over the last five years; the field is now moving from microarray-based technology towards next-generation sequencing. To evaluate the potential of association studies for complex diseases based on exome sequencing we analysed the distribution of association signal with respect to protein-coding...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bipolar Disorder
Share to Crohn Disease
Share to Diabetes Mellitus, Type 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Oligonucleotide Array Sequence Analysis

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 21284873
DOI: 10.1186/1471-2164-12-92
PMCID: PMC3045337

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Exome localization of complex disease association signals.PMID 21284873Read ↗

Exome sequencing as a tool for Mendelian disease gene discovery.Semantic proximity Read ↗

Exome sequencing and complex disease: practical aspects of rare variant association studies.Semantic proximity Read ↗

Exome sequencing and analysis of 454,787 UK Biobank participants.Semantic proximity Read ↗

Exome sequencing: a transformative technology.Semantic proximity Read ↗

Impact of exome sequencing in inflammatory bowel disease.Semantic proximity Read ↗

Analysis of exome sequences with and without incorporating prior biological knowledge.Semantic proximity Read ↗

Enrichment of inflammatory bowel disease and colorectal cancer risk variants in colon expression quantitative trait loci.Semantic proximity Read ↗

Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease.Semantic proximity Read ↗

Exome sequencing of 75 individuals from multiply affected coeliac families and large scale resequencing follow up.Semantic proximity Read ↗

Collaborative science in the next-generation sequencing era: a viewpoint on how to combine exome sequencing data across sites to identify novel disease susceptibility genes.Semantic proximity Read ↗

CAGI4 Crohn's exome challenge: Marker SNP versus exome variant models for assigning risk of Crohn disease.Semantic proximity Read ↗

Inferring Crohn's disease association from exome sequences by integrating biological knowledge.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.