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Article

Stability of the Influenza Virus Hemagglutinin Protein Correlates with Evolutionary Dynamics

8 Jan 2018

Abstract excerpt

One of the constraints on fast-evolving viruses, such as influenza virus, is protein stability, or how strongly the folded protein holds together. Despite the importance of this protein property, there has been limited investigation of the impact of the stability of the influenza virus hemagglutinin protein-the primary antibody target of the immune system-on its evolution. Using a combination of computational...

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PMID: 29299534
DOI: 10.1128/mspheredirect.00554-17

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