Article
Upregulation of miR-18a-5p contributes to epidermal necrolysis in severe drug eruptions.
The Journal of allergy and clinical immunology - 1 Apr 2014
Ichihara Asako, Wang Zhongzhi, Jinnin Masatoshi, Izuno Yuki, Shimozono Naoki, Yamane Keitaro, Fujisawa Akihiko, Moriya Chikako, Fukushima Satoshi, Inoue Yuji, Ihn Hironobu
Abstract excerpt
BACKGROUND: Toxic epidermal necrolysis (TEN) is a severe drug-induced cutaneous reaction. Although one of the primary histologic features of TEN is keratinocyte apoptosis, its exact mechanism remains unknown. OBJECTIVES: We investigated the role of microRNAs (miRNAs) in the pathogenesis of severe drug eruptions and evaluated the possibility that miRNA can be a disease marker. METHODS: miRNAs were extracted from...
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