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Article

Recent advances in the genetics and immunology of Stevens-Johnson syndrome and toxic epidermal necrosis.

Journal of dermatological science - 1 Jun 2012

Chung Wen-Hung, Hung Shuen-Iu

Abstract excerpt

Stevens-Johnson syndrome (SJS) and toxic epidermal necrosis (TEN) are rare but life-threatening severe cutaneous adverse reactions (SCARs), which are majorly (65-75%) induced by a variety of drugs. SJS/TEN could be recognized as SCARs or drug immune reactions, if the reactions are elicited by drugs. The recent studies suggested that SJS/TEN is a specific immune reaction initiated by the cytotoxic T lymphocytes...

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Cytokines
Drug Hypersensitivity
Drug-Induced Adverse Reactions
Genetic Predisposition to Disease
Signal Transduction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Stevens-Johnson Syndrome

T-Lymphocytes, Cytotoxic

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PMID: 22541332
DOI: 10.1016/j.jdermsci.2012.04.002

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