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Viroporin activity of the JC polyomavirus is regulated by interactions with the adaptor protein complex 3

28 Oct 2013

Abstract excerpt

Viroporins, which are encoded by a wide range of animal viruses, oligomerize in host cell membranes and form hydrophilic pores that can disrupt a number of physiological properties of the cell. Little is known about the relationship between host cell proteins and viroporin activity. The human JC polyomavirus (JCV) is the causative agent of progressive multifocal leukoencephalopathy. The JCV-encoded agnoprotein,...

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PMID: 24167297
DOI: 10.1073/pnas.1311457110

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