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Article

Hypoxia-inducible factor 1 regulation through cross talk between mTOR and MT1-MMP.

Molecular and cellular biology - 1 Jan 2014

Sakamoto Takeharu, Weng Jane S, Hara Toshiro, Yoshino Seiko, Kozuka-Hata Hiroko, Oyama Masaaki, Seiki Motoharu

Abstract excerpt

Hypoxia-inducible factor 1 (HIF-1) plays a key role in the cellular adaptation to hypoxia. Although HIF-1 is usually strongly suppressed by posttranslational mechanisms during normoxia, HIF-1 is active and enhances tumorigenicity in malignant tumor cells that express the membrane protease MT1-MMP. The cytoplasmic tail of MT1-MMP, which can bind a HIF-1 suppressor protein called factor inhibiting HIF-1 (FIH-1),...

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Identifiers

PMID: 24164895
DOI: 10.1128/MCB.01169-13
PMCID: PMC3911284

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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