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Article

Tiling array study of MNNG treated Escherichia coli reveals a widespread transcriptional response.

Scientific reports - 25 Oct 2013

Booth James A, Thomassen Gard O S, Rowe Alexander D, Weel-Sneve Ragnhild, Lagesen Karin, Kristiansen Knut I, Bjørås Magnar, Rognes Torbjørn, Lindvall Jessica M

Abstract excerpt

The alkylating agent N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) is known to trigger the adaptive response by inducing the ada-regulon - consisting of three DNA repair enzymes Ada, AlkB, AlkA and the enigmatic AidB. We have applied custom designed tiling arrays to study transcriptional changes in Escherichia coli following a MNNG challenge. Along with the expected upregulation of the adaptive response genes (ada,...

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Identifiers

PMID: 24157950
DOI: 10.1038/srep03053
PMCID: PMC6505713

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Source receipt: pubmed, retrieved 7 Sept 2026.

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