Article
Differential regulation of the REGγ-proteasome pathway by p53/TGF-β signalling and mutant p53 in cancer cells.
Nature communications - 1 Jan 2013
Ali Amjad, Wang Zhuo, Fu Junjiang, Ji Lei, Liu Jiang, Li Lei, Wang Hui, Chen Jiwu, Caulin Carlos, Myers Jeffrey N, Zhang Pei, Xiao Jianru, Zhang Bianhong, Li Xiaotao
Abstract excerpt
Proteasome activity is frequently enhanced in cancer to accelerate metastasis and tumorigenesis. REGγ, a proteasome activator known to promote p53/p21/p16 degradation, is often overexpressed in cancer cells. Here we show that p53/TGF-β signalling inhibits the REGγ-20S proteasome pathway by repressing REGγ expression. Smad3 and p53 interact on the REGγ promoter via the p53RE/SBE region. Conversely, mutant p53...
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