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Proteasome Activator REGγ Enhances Coxsackieviral Infection by Facilitating p53 Degradation

19 Aug 2010

Abstract excerpt

Coxsackievirus B3 (CVB3) is a small RNA virus associated with diseases such as myocarditis, meningitis, and pancreatitis. We have previously demonstrated that proteasome inhibition reduces CVB3 replication and attenuates virus-induced myocarditis. However, the underlying mechanisms by which the ubiquitin/proteasome system regulates CVB replication remain unclear. In this study, we investigated the role of REGγ, a...

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PMID: 20719955
DOI: 10.1128/jvi.00008-10

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