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Article

Neutralisation of specific surface carboxylates speeds up translocation of botulinum neurotoxin type B enzymatic domain.

FEBS letters - 29 Nov 2013

Pirazzini Marco, Henke Tina, Rossetto Ornella, Mahrhold Stefan, Krez Nadja, Rummel Andreas, Montecucco Cesare, Binz Thomas

Abstract excerpt

Botulinum neurotoxins translocate their enzymatic domain across vesicular membranes. The molecular triggers of this process are unknown. Here, we tested the possibility that this is elicited by protonation of conserved surface carboxylates. Glutamate-48, glutamate-653 and aspartate-877 were ident...

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PMID: 24157364
DOI: 10.1016/j.febslet.2013.10.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24157364-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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