Article
Differential effects of human L1CAM mutations on complementing guidance and synaptic defects in Drosophila melanogaster.
PloS one - 1 Jan 2013
Kudumala Sirisha, Freund Julie, Hortsch Michael, Godenschwege Tanja A
Abstract excerpt
A large number of different pathological L1CAM mutations have been identified that result in a broad spectrum of neurological and non-neurological phenotypes. While many of these mutations have been characterized for their effects on homophilic and heterophilic interactions, as well as expression levels in vitro, there are only few studies on their biological consequences in vivo. The single L1-type CAM gene in...
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