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Article

A conserved role for Drosophila Neuroglian and human L1-CAM in central-synapse formation.

Current biology : CB - 10 Jan 2006

Godenschwege Tanja A, Kristiansen Lars V, Uthaman Smitha B, Hortsch Michael, Murphey Rodney K

Abstract excerpt

BACKGROUND: Drosophila Neuroglian (Nrg) and its vertebrate homolog L1-CAM are cell-adhesion molecules (CAM) that have been well studied in early developmental processes. Mutations in the human gene result in a broad spectrum of phenotypes (the CRASH-syndrome) that include devastating neurological disorders such as spasticity and mental retardation. Although the role of L1-CAMs in neurite extension and axon...

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PMID: 16401420
DOI: 10.1016/j.cub.2005.11.062

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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