Article
Identification of genes expressed by immune cells of the colon that are regulated by colorectal cancer-associated variants.
International journal of cancer - 15 May 2014
Peltekova Vanya D, Lemire Mathieu, Qazi Aamer M, Zaidi Syed H E, Trinh Quang M, Bielecki Ryszard, Rogers Marianne, Hodgson Lyndsey, Wang Mike, D'Souza David J A, Zandi Sasan, Chong Taryne, Kwan Jennifer Y Y, Kozak Krystian, De Borja Richard, Timms Lee, Rangrej Jagadish, Volar Milica, Chan-Seng-Yue Michelle, Beck Timothy, Ash Colleen, Lee Shawna, Wang Jianxin, Boutros Paul C, Stein Lincoln D, Dick John E, Gryfe Robert, McPherson John D, Zanke Brent W, Pollett Aaron, Gallinger Steven, Hudson Thomas J
Abstract excerpt
A locus on human chromosome 11q23 tagged by marker rs3802842 was associated with colorectal cancer (CRC) in a genome-wide association study; this finding has been replicated in case-control studies worldwide. In order to identify biologic factors at this locus that are related to the etiopathology of CRC, we used microarray-based target selection methods, coupled to next-generation sequencing, to study 103 kb at...
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