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Article

Association of candidate single nucleotide polymorphisms with somatic mutation of the epidermal growth factor receptor pathway.

BMC medical genomics - 23 Oct 2013

Wormald Samuel, Milla Liz, O'Connor Liam

Abstract excerpt

BACKGROUND: Tumour growth in colorectal cancer and other solid cancers is frequently supported by activating mutations in the epidermal growth factor receptor (EGFR) signaling pathway (Patholog Res Int 2011:932932, 2011). Treatment of metastatic colorectal cancer with targeted anti-EGFR therapeutics such as cetuximab extends survival in only 25% of patients who test wild-type for KRAS, while the majority of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24152305
DOI: 10.1186/1755-8794-6-43
PMCID: PMC4016273

Genes

EGFR
KRAS
TERT
BRAF
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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