Article
Association of E-selectin gene polymorphism and serum PAPP-A with carotid atherosclerosis in end-stage renal disease.
Molecular diagnosis & therapy - 1 Apr 2014
Issac Marianne Samir M, Afif Alaa, Gohar Nadida A, Fayek Nahla A Fawzy, Zayed Bahaa, Sedrak Heba, Salah El Din Lamiaa Adel
Abstract excerpt
BACKGROUND: Atherosclerotic vascular disease represents a significant cause of morbidity and mortality in patients with end-stage renal disease (ESRD). The endothelium plays a crucial role in vascular inflammation. E-selectin is exclusively expressed on activated endothelial cells and is upregulated following an inflammatory response and oxidative stress, while serum pregnancy-associated plasma protein-A (PAPP-A)...
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