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Article

Alteration of innate immunity by donor IL-6 deficiency in a presensitized heart transplant model.

PloS one - 1 Jan 2013

Ge Fangmin, Yuan Shunzong, Su Lida, Shen Zhonghua, He Aibin, Huang Tao, Gong Weihua

Abstract excerpt

Engraftment of IL-6 deficient donor into wild-type recipient could significantly improve allograft survival through T cell lineage particularly regulatory T cells (Tregs) in non-sensitized transplant host. However, its effect on innate immune responses remains uncertain. Our data revealed that donor IL-6 deficiency significantly increased infiltration of two subsets of MDSCs (CD11b+Gr1+myeloid-derived suppressor...

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Identifiers

PMID: 24147024
DOI: 10.1371/journal.pone.0077559
PMCID: PMC3797753

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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