Article
Blocking KCa3.1 channels increases tumor cell killing by a subpopulation of human natural killer lymphocytes.
PloS one - 1 Jan 2013
Koshy Shyny, Wu Danli, Hu Xueyou, Tajhya Rajeev B, Huq Redwan, Khan Fatima S, Pennington Michael W, Wulff Heike, Yotnda Patricia, Beeton Christine
Abstract excerpt
Natural killer (NK) cells are large granular lymphocytes that participate in both innate and adaptive immune responses against tumors and pathogens. They are also involved in other conditions, including organ rejection, graft-versus-host disease, recurrent spontaneous abortions, and autoimmune diseases such as multiple sclerosis. We demonstrate that human NK cells express the potassium channels Kv1.3 and KCa3.1....
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