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Article

Coding and non-coding RNA expression in NSC34 cells following TDP-43 depletion and mutant TDP-43 M337V expression.

Scientific data - 1 Jul 2025

Gbadamosi Ismail, Binias Sandra, Gielniewski Bartłomiej, Magno Ramiro, Duarte Isabel, Jawaid Ali

Abstract excerpt

Several neurodegenerative disorders (NDDs), notably amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are characterized by pathological cytoplasmic aggregation of TAR DNA-binding protein 43 (TDP-43) in neurons and glia. Primarily localized in the nucleus under physiological conditions, TDP-43 is a critical regulator of RNA processing and metabolism. Therefore, RNA changes induced by...

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Topics

DNA-Binding Proteins
Mutation
Amyotrophic Lateral Sclerosis
Mice
Motor Neurons
Animals

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Humans

Cell Line

RNA, Untranslated

Transcriptome

RNA Interference

Source

Open in PubMed Open full text

Identifiers

PMID: 40593943
DOI: 10.1038/s41597-025-05409-7
PMCID: PMC12218450

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