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Article

The sex hormone system in carriers of BRCA1/2 mutations: a case-control study.

The Lancet. Oncology - 1 Nov 2013

Widschwendter Martin, Rosenthal Adam N, Philpott Sue, Rizzuto Ivana, Fraser Lindsay, Hayward Jane, Intermaggio Maria P, Edlund Christopher K, Ramus Susan J, Gayther Simon A, Dubeau Louis, Fourkala Evangelia Ourania, Zaikin Alexey, Menon Usha, Jacobs Ian J

Abstract excerpt

BACKGROUND: Penetrance for breast cancer, ovarian cancer, or both in carriers of BRCA1/BRCA2 mutations is disproportionately high. Sex hormone dysregulation and altered end-organ hormone sensitivity might explain this organ-specific penetrance. We sought to identify differences in hormone regulation between carriers of BRCA1/2 and women who are negative for BRCA1/2 mutations. METHODS: We assessed endometrial...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24140203
DOI: 10.1016/S1470-2045(13)70448-0

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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