Breast Cancer Risk Associated with Estrogen Exposure and Truncating Mutation Location in BRCA1/2 Carriers.

doi:10.1158/1055-9965.EPI-14-0884

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Article

Breast Cancer Risk Associated with Estrogen Exposure and Truncating Mutation Location in BRCA1/2 Carriers.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Apr 2015

Lecarpentier Julie, Noguès Catherine, Mouret-Fourme Emmanuelle, Buecher Bruno, Gauthier-Villars Marion, Stoppa-Lyonnet Dominique, Bonadona Valérie, Fricker Jean-Pierre, Berthet Pascaline, Caron Olivier, Coupier Isabelle, Pujol Pascal, Faivre Laurence, Gesta Paul, Eisinger François, Mari Véronique, Gladieff Laurence, Lortholary Alain, Luporsi Elisabeth, Leroux Dominique, Venat-Bouvet Laurence, Maugard Christine M, Colas Chrystelle, Tinat Julie, Lasset Christine, Andrieu Nadine

Abstract excerpt

BACKGROUND: Mutations in BRCA1/2 confer a high risk of breast cancer, but literature values of this risk vary. A genotype-phenotype correlation has been found in both genes, and the effect of reproductive factors differs according to mutation location. Therefore, we hypothesize that such a variation may exist for other factors related to estrogen exposure. METHODS: We used a weighted Cox regression model to...

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PMID: 25613119
DOI: 10.1158/1055-9965.EPI-14-0884

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BRCA1
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