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Article

The Role of Hormonal Replacement Therapy in BRCA Mutated Patients: Lights and Shadows.

International journal of molecular sciences - 1 Jan 2023

Loizzi Vera, Dellino Miriam, Cerbone Marco, Arezzo Francesca, Cazzato Gerardo, Damiani Gianluca Raffaello, Pinto Vincenzo, Silvestris Erica, Kardhashi Anila, Cicinelli Ettore, Cascardi Eliano, Cormio Gennaro

Abstract excerpt

All cancers develop as a result of mutations in genes. DNA damage induces genomic instability and subsequently increases susceptibility to tumorigenesis. Women who carry mutations of BRCA 1 and BRCA2 genes have an augmented risk of breast and ovarian cancer and a markedly augmented probability of dying because of cancer compared to the general population. As a result, international guidelines recommend that all...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 36614207
DOI: 10.3390/ijms24010764
PMCID: PMC9821191

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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