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Article

Structure of mediator of RhoA-dependent invasion (MRDI) explains its dual function as a metabolic enzyme and a mediator of cell invasion.

Biochemistry - 20 Aug 2013

Templeton Paul D, Litman Elizabeth S, Metzner Sandra I, Ahn Natalie G, Sousa Marcelo C

Abstract excerpt

Metastatic melanoma is among the most intractable cancers to treat; patients show resistance to therapy and limited survival time. A critical step in the development of metastatic melanoma is the acquisition of invasion and transition from thin to thick tumors on the skin, followed by invasion to lymph nodes. Prior studies have shown that metastatic melanoma is associated with dysregulation of RhoA and enhanced...

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Identifiers

PMID: 23859498
DOI: 10.1021/bi400556e
PMCID: PMC3831603

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MTR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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