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Article

Clinical phenotype matters: structural and functional thalamic changes in neuropathic low-back pain.

Pain - 1 Apr 2026

Yuan Ruiyi, Cole Martin, Gewandter Jennifer, Markman John, Zhang Zhengwu, Geha Paul

Abstract excerpt

ABSTRACT: Neuropathic chronic low-back pain (neuCLBP) is associated with worse clinical outcomes compared with non-neuropathic or axial CLBP (non-neuCLBP) and has limited effective nonsurgical treatment options, reflecting poor understanding of its underlying pathophysiology. In this study, we compared neuCLBP and non-neuCLBP patients using standardized clinical phenotyping of the neuropathic component alongside...

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Identifiers

PMID: 41325555
DOI: 10.1097/j.pain.0000000000003843

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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