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Article

Association of CYP3A5 polymorphisms and parathyroid hormone with blood level of tacrolimus in patients with end-stage renal disease.

Clinical and translational science - 1 Sept 2021

Tanaka Ryota, Suzuki Yosuke, Watanabe Hiroshi, Fujioka Takashi, Hirata Kenshiro, Shin Toshitaka, Ando Tadasuke, Ono Hiroyuki, Tatsuta Ryosuke, Mimata Hiromitsu, Maruyama Toru, Itoh Hiroki

Abstract excerpt

Because tacrolimus is predominantly metabolized by CYP3A, the blood concentration/dose (C/D) ratio is affected by CYP3A5 polymorphism. Parathyroid hormone (PTH) expression increases in secondary hyperparathyroidism, which is frequently associated with end-stage renal disease. Recently, PTH has been shown to downregulate CYP3A expression at mRNA level. In this study, we examined the influence of CYP3A5...

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Share to Cytochrome P-450 CYP3A
Share to Dose-Response Relationship, Drug

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Graft Rejection

Share to Kidney Failure, Chronic

Share to Kidney Transplantation

Share to Parathyroid Hormone

Share to Pharmacogenomic Variants

Share to Tacrolimus

Source

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Identifiers

PMID: 34058078
DOI: 10.1111/cts.13065
PMCID: PMC8504850

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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