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Article

Somatic mutations in PIK3CA and activation of AKT in intraductal tubulopapillary neoplasms of the pancreas.

The American journal of surgical pathology - 1 Dec 2011

Yamaguchi Hiroshi, Kuboki Yuko, Hatori Takashi, Yamamoto Masakazu, Shiratori Keiko, Kawamura Shunji, Kobayashi Makio, Shimizu Michio, Ban Shinichi, Koyama Isamu, Higashi Morihiro, Shin Nobuhiro, Ishida Kazuyuki, Morikawa Takanori, Motoi Fuyuhiko, Unno Michiaki, Kanno Atsushi, Satoh Kennichi, Shimosegawa Tooru, Orikasa Hideki, Watanabe Tomoo, Nishimura Kazuhiko, Harada Youji, Furukawa Toru

Abstract excerpt

Intraductal tubulopapillary neoplasm (ITPN) is a recently recognized rare variant of intraductal neoplasms of the pancreas. Molecular aberrations underlying the neoplasm remain unknown. We investigated somatic mutations in PIK3CA, PTEN, AKT1, KRAS, and BRAF. We also investigated aberrant expressions of phosphorylated AKT, phosphatase and tensin homolog (PTEN), tumor protein 53 (TP53), SMAD4, and CTNNB1 in 11...

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Source

Identifiers

PMID: 21945955
DOI: 10.1097/PAS.0b013e31822769a0

Genes

KRAS
CTNNB1
PTEN
SMAD4
AKT1
BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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