Article
Whole genome methylation array analysis reveals new aspects in Balkan endemic nephropathy etiology.
BMC nephrology - 16 Oct 2013
Staneva Rada, Rukova Blaga, Hadjidekova Savina, Nesheva Desislava, Antonova Olga, Dimitrov Plamen, Simeonov Valeri, Stamenov Georgi, Cukuranovic Rade, Cukuranovic Jovana, Stefanovic Vladislav, Polenakovic Momir, Dimova Ivanka, Hlushchuk Ruslan, Djonov Valentin, Galabov Angel, Toncheva Draga
Abstract excerpt
BACKGROUND: Balkan endemic nephropathy (BEN) represents a chronic progressive interstitial nephritis in striking correlation with uroepithelial tumours of the upper urinary tract. The disease has endemic distribution in the Danube river regions in several Balkan countries.DNA methylation is a primary epigenetic modification that is involved in major processes such as cancer, genomic imprinting, gene silencing,...
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