Identification of NQO1 and GSTs genotype frequencies in Bulgarian patients with Balkan endemic nephropathy.

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Article

Identification of NQO1 and GSTs genotype frequencies in Bulgarian patients with Balkan endemic nephropathy.

Journal of nephrology - 1 Jan 2000

Toncheva Draga I, Von Ahsen Nicolas, Atanasova Srebrena Y, Dimitrov Tzvetan G, Armstrong Victor W, Oellerich Michael

Abstract excerpt

BACKGROUND: Polymorphisms in NAD[P]H:quinone oxidoreductase (NQO1) and glutathione S-transferases (GSTs) have been reported to be associated with an increased risk for environmentally and/or occupationally induced renal and bladder cancers. Genetic factors related to chronic nephropathy and to urinary bladder or renal cancer development in Balkan endemic nephropathy (BEN) is unknown. In order to evaluate their...

Topics

Balkan Nephropathy
Bulgaria
Female
Gene Frequency
Genetic Predisposition to Disease
Genotype
Glutathione Transferase
Humans
Male
Middle Aged
NAD(P)H Dehydrogenase (Quinone)
Polymerase Chain Reaction
Polymorphism, Genetic

Source

Open in PubMed

Identifiers

PMID: 15365958

Genes

NQO1
GSTM1
GSTT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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