Article
Increased levels of PD-1 expression on CD8 T cells in patients post-renal transplant irrespective of chronic high EBV viral load.
Pediatric transplantation - 1 Dec 2013
Moran Julie, Dean Jonathan, De Oliveira Andre, O'Connell Marie, Riordan Michael, Connell Jeff, Awan Atif, Hall William W, Hassan Jaythoon
Abstract excerpt
Studies have identified solid organ transplant recipients who remain asymptomatic despite maintaining CHL. Factors which determine the CHL state remain poorly understood but are likely to involve immunological control of the viral infection. We monitored expression of PD-1, a marker of T-cell exhaustion and viral persistence, on CD8 T cells in patients who resolved EBV infection as determined by undetectable EBV...
Topics
- Adolescent
- Antigens, Viral
- CD8-Positive T-Lymphocytes
- Child
- Child, Preschool
- Chronic Disease
- Cohort Studies
- Epstein-Barr Virus Infections
- Female
- Gene Expression Profiling
- Humans
- Immunosuppression Therapy
- Immunosuppressive Agents