Article
Association of a potential functional pre-miR-218 polymorphism and its interaction with hepatitis B virus mutations with hepatocellular carcinoma risk.
Liver international : official journal of the International Association for the Study of the Liver - 1 May 2014
Han Yifang, Pu Rui, Han Xue, Zhao Jun, Li Weiping, Yin Jianhua, Zhang Yuwei, Shen Qiuxia, Xie Jiaxin, Zhang Qi, Jiang Shuang, Li Juhong, Zhang Hongwei, Wang Hongyang, Cao Guangwen
Abstract excerpt
BACKGROUND & AIMS: MicroRNA-218 (miR-218) can function as a tumour suppressor and inactivate cancer-promoting inflammation. However, role of miR-218 on hepatocellular carcinoma (HCC) remains unclear. To determine the contribution of miR-218 genetic predisposition and its interaction with hepatitis B virus (HBV) mutations to HCC risk. METHODS: rs11134527 located at putative promoter region of pre-miR-218 was...
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