Article
Associations of pri-miR-34b/c and pre-miR-196a2 polymorphisms and their multiplicative interactions with hepatitis B virus mutations with hepatocellular carcinoma risk.
PloS one - 1 Jan 2013
Han Yifang, Pu Rui, Han Xue, Zhao Jun, Zhang Yuwei, Zhang Qi, Yin Jianhua, Xie Jiaxin, Shen Qiuxia, Deng Yang, Ding Yibo, Li Weiping, Li Juhong, Zhang Hongwei, Cao Guangwen
Abstract excerpt
BACKGROUND: Genetic polymorphisms of pri-miR-34b/c and pre-miR-196a2 have been reported to be associated with the susceptibility to cancers. However, the effect of these polymorphisms and their interactions with hepatitis B virus (HBV) mutations on the development of hepatocellular carcinoma (HCC) remains largely unknown. We hypothesized that these polymorphisms might interact with the HBV mutations and play a...
Topics
- Carcinoma, Hepatocellular
- Epistasis, Genetic
- Female
- Genetic Predisposition to Disease
- Hepatitis B virus
- Humans
- Liver Neoplasms
- Male
- MicroRNAs
- Mutation