Article
Mutation in the kv3.3 voltage-gated potassium channel causing spinocerebellar ataxia 13 disrupts sound-localization mechanisms.
PloS one - 1 Jan 2013
Middlebrooks John C, Nick Harry S, Subramony S H, Advincula Joel, Rosales Raymond L, Lee Lillian V, Ashizawa Tetsuo, Waters Michael F
Abstract excerpt
Normal sound localization requires precise comparisons of sound timing and pressure levels between the two ears. The primary localization cues are interaural time differences, ITD, and interaural level differences, ILD. Voltage-gated potassium channels, including Kv3.3, are highly expressed in th...
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