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Article

Shank3 mutations enhance early neural responses to deviant tones in dogs.

Cerebral cortex (New York, N.Y. : 1991) - 9 Oct 2023

Wu Liang, Mei Shuting, Yu Shan, Han Shihui, Zhang Yong Q

Abstract excerpt

Both enhanced discrimination of low-level features of auditory stimuli and mutations of SHANK3 (a gene that encodes a synaptic scaffolding protein) have been identified in autism spectrum disorder patients. However, experimental evidence regarding whether SHANK3 mutations lead to enhanced neural processing of low-level features of auditory stimuli is lacking. The present study investigated this possibility by...

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PMID: 37585733
DOI: 10.1093/cercor/bhad302

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