Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Meta-analysis identifies NF-κB as a therapeutic target in renal cancer.

PloS one - 1 Jan 2013

Peri Suraj, Devarajan Karthik, Yang Dong-Hua, Knudson Alfred G, Balachandran Siddharth

Abstract excerpt

OBJECTIVE: To determine the expression patterns of NF-κB regulators and target genes in clear cell renal cell carcinoma (ccRCC), their correlation with von Hippel Lindau (VHL) mutational status, and their association with survival outcomes. METHODS: Meta-analyses were carried out on published ccRCC gene expression datasets by RankProd, a non-parametric statistical method. DEGs with a False Discovery Rate of <...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Renal Cell
Share to Cysteine Endopeptidases
Share to I-kappa B Kinase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interferons

Share to Kidney Neoplasms

Share to Matrix Metalloproteinase 9

Share to NF-kappa B

Share to Von Hippel-Lindau Tumor Suppressor Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 24116146
DOI: 10.1371/journal.pone.0076746
PMCID: PMC3792024

Genes

VHL
IKBKB
MMP9
PSMB9
SOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Meta-analysis identifies NF-κB as a therapeutic target in renal cancer.PMID 24116146Read ↗

Comprehensive Multi-Omics Identification of Interferon-γ Response Characteristics Reveals That RBCK1 Regulates the Immunosuppressive Microenvironment of Renal Cell Carcinoma.Semantic proximity Read ↗

NF1/2 mutations predict favorable benefit from immune checkpoint inhibitor-based therapies over VEGFR/mTOR inhibitors in clear cell renal cell carcinoma.Semantic proximity Read ↗

Gene expression profiling of anti-GBM glomerulonephritis model: The role of NF-κB in immune complex kidney diseaseSemantic proximity Read ↗

Multiple tumor suppressors regulate a HIF-dependent negative feedback loop via ISGF3 in human clear cell renal cancerSemantic proximity Read ↗

Integrative Clinical and Molecular Evaluation of Renal Cell Carcinoma with Merlin Protein Deficiency and Biallelic Loss of NF2.Semantic proximity Read ↗

Identification and characterisation of HNF1B as a pro-tumorigenic lineage factor in clear cell renal cell carcinomaSemantic proximity Read ↗

The Notch and TGF-β Signaling Pathways Contribute to the Aggressiveness of Clear Cell Renal Cell CarcinomaSemantic proximity Read ↗

High VHL Expression Reverses Warburg Phenotype and Enhances Immunogenicity in Kidney Tumor Cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.