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Article

Integrative Clinical and Molecular Evaluation of Renal Cell Carcinoma with Merlin Protein Deficiency and Biallelic Loss of NF2.

Clinical cancer research : an official journal of the American Association for Cancer Research - 16 Mar 2026

Yekedüz Emre, Bian Weiwei, Siegmund Stephanie E, Machaalani Marc, El Masri Jad, Saleh Mustafa, Saad Eddy, Ascione Liliana, El Hajj Chehade Razane, Steiner Clara, Barrios Pablo Moura, Berg Stephanie A, McGregor Bradley, Mantia Charlene, Ravi Praful, Xu Wenxin, Hirsch Michelle S, Choueiri Toni K, Serzan Michael

Abstract excerpt

PURPOSE: In renal cell carcinoma (RCC), loss of the NF2 tumor suppressor gene encoding the merlin protein is associated with aggressive clinical behavior. However, data about the clinical course and additional molecular features in the context of contemporary systemic therapies remain limited. EXPERIMENTAL DESIGN: Clinical outcomes were evaluated in patients with RCC exhibiting merlin loss by IHC in one academic...

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Aged
Alleles
Biomarkers, Tumor
Carcinoma, Renal Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Expression Regulation, Neoplastic

Kidney Neoplasms

Neurofibromin 2

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Identifiers

PMID: 41524698
DOI: 10.1158/1078-0432.CCR-25-2871
PMCID: PMC12924687

Genes

NF2
CDKN2A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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