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Article

Clinical and hematological characteristics of beta-plus thalassemia and uncommon beta-chain hemoglobin variants in Northern Thailand.

Annals of medicine - 1 Dec 2025

Rukwong Punwadee, Natesirinilkul Rungrote, Sathitsamitphong Lalita, Choed-Amphai Chane, Tantiworawit Adisak, Fanhchaksai Kanda, Maneekesorn Supawadee, Charoenkwan Pimlak

Abstract excerpt

BACKGROUND: Thalassemia is the most common hereditary anemia worldwide. Beta-thalassemia results from mutations in HBB gene, causing either absent (β0) or decreased (β+) production of β-globin. Mutations causing β+-thalassemia comprise 10-20%of HBB mutations in Thailand. However, their clinical characteristics are poorly characterized. OBJECTIVES: To describe the clinical and hematological characteristics of...

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Topics

Humans
Thailand
beta-Thalassemia
Female
Male
Adult

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Retrospective Studies

beta-Globins

Adolescent

Mutation

Young Adult

Child

Hemoglobins, Abnormal

Middle Aged

Hemoglobin E

Child, Preschool

Blood Transfusion

Source

Open in PubMed Open full text

Identifiers

PMID: 40888401
DOI: 10.1080/07853890.2025.2551815
PMCID: PMC12404072

Genes

HBB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 15 Oct 2026.

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