Article
Molecular basis of non-deletional HPFH in Thailand and identification of two novel mutations at the binding sites of CCAAT and GATA-1 transcription factors.
Scientific reports - 24 Jul 2023
Singha Kritsada, Pansuwan Anupong, Chewasateanchai Mattanee, Fucharoen Goonnapa, Fucharoen Supan
Abstract excerpt
High Hb F determinants are genetic defects associated with increased expression of hemoglobin F in adult life, classified as deletional and non-deletional forms. We report the first description of non-deletional hereditary persistence of fetal hemoglobin (HFPH) in Thailand. Study was done on 388 subjects suspected of non-deletional HPFH with elevated Hb F expression. Mutations in the Gγ- and Aγ-globin genes were...
Topics
- Adult
- Humans
- GATA Transcription Factors
- Thailand
- gamma-Globins
- Binding Sites
- Transcription Factors
- Fetal Hemoglobin
- Mutation