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O 6 -methylguanine DNA methyltransferase gene promoter methylation in high-grade gliomas: A review of current status

1 Jan 2011

Abstract excerpt

Assessment of promoter methylation of the O 6 -methylguanine DNA methyltransferase (MGMT) gene has recently gained importance in molecular profiling of high-grade gliomas. It has emerged not only as an important prognostic marker but also as a predictive marker for response to temozolomide in patients with newly diagnosed glioblastoma. Further, recent studies indicate that MGMT promoter methylation has strong...

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PMID: 21483124
DOI: 10.4103/0028-3886.79128

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