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Article

Cell-cell adhesion genes CTNNA2 and CTNNA3 are tumour suppressors frequently mutated in laryngeal carcinomas.

Nature communications - 1 Jan 2013

Fanjul-Fernández Miriam, Quesada Víctor, Cabanillas Rubén, Cadiñanos Juan, Fontanil Tania, Obaya Alvaro, Ramsay Andrew J, Llorente José L, Astudillo Aurora, Cal Santiago, López-Otín Carlos

Abstract excerpt

Laryngeal squamous cell carcinoma is a frequent and significant cause of morbidity and mortality. Here we explore the biological basis of this aggressive tumour, and identify two cell-cell adhesion genes as recurrently mutated in this malignancy. We first perform exome sequencing of four laryngeal carcinomas and their matched normal tissues. Among the 569 genes found to present somatic mutations, and based on...

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Source

Identifiers

PMID: 24100690
DOI: 10.1038/ncomms3531

Genes

CTNNA2
CTNNA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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