Article
The presence of CXCR4-using HIV-1 prior to start of antiretroviral therapy is an independent predictor of delayed viral suppression.
PloS one - 1 Jan 2013
Gijsbers Esther F, van Sighem Ard, Harskamp Agnes M, Welkers Matthijs R A, de Wolf Frank, Brinkman Kees, Prins Jan M, Schuitemaker Hanneke, van 't Wout Angélique B, Kootstra Neeltje A
Abstract excerpt
The emergence of CXCR4-using HIV variants (X4-HIV) is associated with accelerated disease progression in the absence of antiretroviral therapy. However, the effect of X4-HIV variants on the treatment response remains unclear. Here we determined whether the presence of X4-HIV variants influenced the time to undetectable viral load and CD4+ T cell reconstitution after initiation of cART in 732 patients. The...
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