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Article

CXCR4 overexpression during the course of HIV-1 infection correlates with the emergence of X4 strains.

Journal of acquired immune deficiency syndromes (1999) - 15 Aug 2005

Lin Yea-Lih, Portales Pierre, Segondy Michel, Baillat Vincent, de Boever Corinne Merle, Le Moing Vincent, Réant Brigitte, Montes Brigitte, Clot Jacques, Reynes Jacques, Corbeau Pierre

Abstract excerpt

The factors that determine the emergence of X4 isolates in some HIV-1-infected subjects are unknown. As the level of expression of CXCR4 could favor an R5 to X4 switch, quantitative flow cytometry was used to measure CXCR4 density on CD4 T cells in 200 HIV-1-positive adults, and this was compared with CD4 counts, interleukin-7 (IL-7), and RANTES (regulated on activation, normal T expressed and secreted) plasma...

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Share to CD4 Lymphocyte Count
Share to CD4-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chemokine CCL5

Share to HIV Infections

Share to Interleukin-7

Share to Receptors, CXCR4

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Source

Identifiers

PMID: 16044003

Genes

CXCR4

Provenance

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